YURI M. LVOV
Current Position Professor, Tolbert Pipes Eminent Endowed Chair on Micro and Nanosystems, Institute for Micromanufacturing, Louisiana Tech University, 911 Hergot Ave.,
Ruston, LA 71272 USA
Education
· PhD in Physical Chemistry, Moscow State University, 1979. Thesis title: “Small-Angle X-ray and Neutron Structural Analysis of Histidine Decarboxylase.”
· BS in Physics, Moscow State University, Russia, 1974.
Honors/Awards
●Medal for Best Research Achievements from Louisiana Tech University, 2005
●Tolbert Pipes Eminent Endowed Chair on Micro and Nanosystem, 2004.
●In 2004, Institute of Scientific Information ranked our article in “Langmuir,” v.9, p.481, among three most cited papers on molecular self-assembly (citations: 370), and another my paper on protein architecture in the Journal of American Chemical Society, 1995, v.117, p.6177 was cited 570 times which makes it #5 most cited chemistry paper with Japanese co-authors. A total citation of my papers on nanoassembly is above 2,600.
●Award Certificate from American Chemical Society for organization of “Smart Nanoassemblies” Symposium at 226th ACS National Meeting in New York, September 2003.
●Royal Chemical Society Publication Award, 1999, UK;
●Alexander von Humboldt Fellowship, 1991-1993, Germany;
●Earned Doctor of Science in Physics from Moscow State University, 1991, Russia.
Experience
2004-now Professor of Chemistry, T. Pipes Eminent Endowed Chair on Micro and Nanosystems, Institute for Micromanufacturing, and Affiliated Faculty at Biomedical Engineering Department, Louisiana Tech University, Ruston, LA. President of Nano Pulp and Paper, LLC
1999-2003 Associate Professor, Institute for Micromanufacturing and Chemistry Program, Affiliated Faculty in the Physics and Biomedical Engineering Departments, Louisiana Tech University, Ruston, LA.
1998-1999 Research Associate Professor, Center Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington DC.
1997-1998 Research Assistant and Adjunct Professor, Chemistry Department, University of Connecticut, Storrs, CT.
1994-1996 Staff Researcher, Research & Development Corporation, Japan Science Agency, Fukuoka.
1991-1993 Alexander von Humboldt Fellowship, Mainz University, Institute of Physical Chemistry, Germany.
1980-1990 Senior Researcher, Thin film group leader, Institute of Crystallography, Russian Academy of Sciences, Moscow.
Temporary Visiting Scientist, Materials Directorate, Wright - Patterson Air Force Base, Dayton, OH,
Positions: September 1997.
Visiting Professor, Molecular Electronics Center, Durham University, UK, April-May 1999.
Adjunct Professor in Pharmaceutics in the Department of Pharmaceutical Sciences at University of Louisiana in Monroe, 2003-2006.
Scientific/Professional Societies
Alexander von Humboldt Foundation, since 1991. American Chemical Society, since 1994.
TAPPI (Technical Association for Pulp and Paper Industry) member since 2004
Research grants and contracts - my group funding exceeded $ 4 mln from more than $ 10 million of my total (with co-PIs) grants’ budget in the last five years
1. “Nanoengineered Shells for Encapsulation and Controlled Release,” PI, budget $899,050; NSF-NIRT 0210298, Sept 2002-Aug 2007.
2. “Fluorescent Glucose Sensors from Polyion Shells,” co-PI, $1,329,000; NIH-1RO1 EB00739-01; Sept 02-Aug 07.
3. “Protein Drug Microencapsulation,” Epic Therapeutic Incorporation contract, PI, $270,000; May 2004 - Nov 2006
4. “LbL-Nanoassembly for Pulp Treatment,” SAPPI Fine Paper Corporation contract, PI, $120,000; Jan 2006 - Jan 2007
5. “Nanotechnology for Pulp and Paper Industry: Layer-by-Layer Polyelectrolyte Coating,” PI, LA Board of Regent Industry Ties Program, $180,000; July 1, 2005 – June 30, 2008.
6. “Research and Education: Increasing Student Participation in Research at Internationally Recognized User Facilities,” co-PI, NSF, $200,000; Sept 2005- August 2008.
7. “Understanding the Local Atomic-Level Effect of Dopant in Complex Metal Hydrides, Using Synchrotron X-Ray Absorption Spectroscopy (XAS)” co-PI, DoE, $300,000 Sept 2005-August 2008
8. “Acquisition of Field Emission Scanning Electron Microscope,” co-PI, NSF, $523,000, Sept 2005 - Dec 2006
9. “Teaching Nanosystem Engineering to Early College Students with Active Learning Experience,” NSF-NUE, co-PI, June 2004 – August 2006, $150,000.
Successfully Concluded:
10. “Nanoscale Biotechnology: Materials, Methods, Devices,” co-PI, Louisiana Governor Biotechnology Initiative, $1,950,000 Jan 2005- December 2006.
11. “Smart Nano Pulp and Paper,” co-PI, DARPA/NAVY-spavar, $1,000,000 January 2005-August 2006
12. “Self-Assembly of Microshells with Nanoorganized Walls for Drug Encapsulation”, PI, Louisiana Board of Regents 2002/05-RDA19, budget $150,000; July 2002-June 2005.
13. “Nanoparticle Technology for DNA-Repair Enzyme Delivery,” co-PI, budget of $1,458,000; Dec 2001- January 2005, NASA: NAS2-02059.
14. “Micro / Nanodevices and Systems for Biochemical Sensors and Signaling,” co-PI, budget of $2,920,000. June 2001 – December 2004. NSF-LEQSF 0092001.
15. “Biosystems Nanomanufacturing Research and Development Center” Louisiana BoR, PI, $50,000; Sept 2003-March 2005.
16. “Optimization of polyion coating for specific adsorption of progesterone and estradiol,” PI, budget $120,000, contract with Ciba-Vision Corporation, March 2003-June 2004.
17. “Nanoconstruction on Microtemplates,” PI, $60,000, Sept 2000 – December 2002, Source of support: American Chemical Society-Petroleum Fund: 36066-AC5.
18. “Layer-by-Layer Immobilization of Organophosphorus Anhydrase,” PI, Naval Research Lab contract 01-P-1567, Office of Naval Research contract 01-P-1567, PI, $50,000; July 2001- April 2002.
Patents
1) “Multiple Layered Functional Thin Films,” M. Onda, Y. Lvov, K. Ariga, T. Kunitake February 1, 2000, US patent 6020175.
2) “Fluorescent Sensors Based on Encapsulation of Indicator Dyes with Polyion Shells,” Inventors: M. McShane, Y. Lvov. US Patent Application 10/360,328 from February 7, 2003.
3) “Lithographically-Based Approach to Pattern Layer-by-Layer Nano-assembled Thin Films for Microelectronics / MEMS Devices,” Inventors: T. Cui, Y. Lvov, F. Hua. US patent application 10/387,769 from March 13, 2003.
4) “Sustained Drug Release from Nanoorganized Polyion Microcapsules,” filed on 8-Jan-05, US patent application # 60/535,664.
5) “Preparation of Protein Ultrathin Films Using Alternate Adsorption Technique,” T. Kunitake, K. Ariga, Y. Lvov; September 24, 1996, Japanese patent 8-245815.
6) Y. Lvov, Z. Zheng, L. Guice, “Paper and pulp nano/coating by multistep adsorption of oppositely charged linear polyions, nanoparticles, proteins and DNA,” filed April 30, 2005, US patent application number # 60/661,640
Disclosures to LaTech and Patent Applications - Fourteen disclosures were submitted to LaTech and four of them were promoted to patent applications.
Publications
a. Articles Total – 150 articles published in peer reviewed journals; 25 most important articles are given below:
1. Z. Zheng, J. McDonald, T. Shutava, G. Grozdits, Y. Lvov, J. Nanoscience Nanotechnology, v.6, 324-332, 2006, “Layer-by-Layer Nanocoating of Lignocellulose Fibers for Enhanced Paper Properties”
2. N. Pargaonkar, Y. Lvov, M. de Villiers, Pharmaceutical Res., v.22, 826-835, 2005, “Controlled Release of Dexamethasone from Microcapsules Produced by Polyelectrolyte Layer-by-Layer Nanoassembly.”
3. D. Kommireddy, T. Shutava, D. Mills, Y. Lvov, J. Nanoscience Nanotechnology, v.5, 1081-1087, 2005, “Layer-by-Layer Assembly of TiO2 Nanoparticle for Stable Hydrophilic Biocompatible Coating”
4. T. Shutava, M. Prouty, Y. Lvov, Macromolecules, 2005, v.38, 2850-2856, “pH Responsible Decomposable Layer-by-Layer Films and Capsules on the Basis of Tannic Acid”
5. D. Shchukin, R. Price, G. Sukhorukov, Y. Lvov, Small (Nano- Micro), v.1, 510-513, 2005, “Biomimetic Synthesis of Vaterite in the Interior of Clay Nanotubules”
6. D. Shchukin, G. Sukhorukov, Y. Lvov, J. Am. Chem. Society, 2004, v.126, 3374-3376, “Nanoassembly of Biodegradable Microcapsules for DNA Encasing”
7. T. Cui, Y. Lvov, IEEE Electronic Devices, 2004, v.51, 503-507 “Field Effect Transistor Fabricated by Electrostatic Layer-by-Layer Nanoassembly”
8. F. Hua, T. Cui, Y. Lvov, Nano Letter, 2004, v.4, 878-882, “Ultrathin Cantilevers Based on Polymer-Ceramic Nanocomposite Assembled through Layer-by-Layer Adsorption”
9. D. Shchukin, T. Cui, G. Sukhorukov, Y. Lvov, Advanced Materials, 2004, v.16, 389-393, “Fabrication of Polyelectrolyte/Protein Microarrays Using a Laminar Flow Microfluidic Device”
10. T. Shutava, V. John, Y. Lvov, Biomacromolecules, 2004, v.5, 914-921, “Microcapsule Modification with Peroxidase Catalyzed Phenol Polymerization”
11. R. Ghan, T. Shutava, V. John, Y. Lvov, Macromolecules, 2004, v.37, 4519, “Enzyme Catalyzed Polymerization of Phenols within Polyelectrolyte Microcapsules”
12. F. Hua, Y. Lvov, T. Cui, Thin Solid Films, 2004, v.449, 222-225, “A Lithographic Approach of Spatial Separation for Multiple Types of Layer-by-Layer Self-Assembled Nanoparticles”
13. H. Ai, Y. Lvov, S. Jones, Cell Biochemistry and Biophysics, 2003, v.39, 23-43, “Biomedical Applications of Electrostatic Layer-by-Layer Nano-Assembly of Polymers, Enzymes and Nanoparticles”
14. H. Ai, S. Jones, M. de Villiers, Y. Lvov, J. Controlled Release, 2003, v.86, 59-66, “Nanoencapsulation of Furosemide Microcrystals for Controlled Drug Release”
15. F. Hua, Y. Lvov, T. Cui, Nanotechnology, 2003, v.14, 453-457, “Fabrication and Characterization of Capacitor Based on Layer-by-Layer Self-Assembled Thin Films”
16. F. Hua, Y. Lvov, T. Cui, Nano Letters, 2002, v.2, 1219-1222, “Patterning of Layer-by-layer Self-assembled Multiple Types of Nanoparticle Thin Films by Lithographic Technique
17. F. Hua, Y. Lvov, Langmuir, 2002, v.18, 6712-6715, “Lithographic Approach to Pattern Self-Assembled Polyelectrolyte Multilayers”
18. M. McShane, J. Brown, K. Guice, Y. Lvov, J. Nanoscience and Nanotechnology, 2002, v.2, 411-416, “Polyelectrolyte Microshells as Carriers for Fluorescent Sensors: Loading and Sensing Properties of a Ruthenium-Based Oxygen Indicator”
20. Y. Lvov, F. Caruso, Analytical Chemistry, 2001, v.73, 4212-4217, “Biocolloids with Ordered Urease Multilayer Shells as Enzymatic Reactors”
21. Y. Lvov, A. Antipov, H. Möhwald, G. Sukhorukov, Nano Letters, 2001, v.1, 125-128, “Urease Encapsulation in Nano/organized Microshells”
22. Y. Lvov, R. Price, A. Singh, J. Selinger, J. Schnur, Langmuir, 2000, v.16, 5932-5935, “Nanoscale Patterning on Biologically Derived Microstructures”
23. Y. Lvov, J. Schenkman, J. Rusling, J. Am. Chemical Society, 1998, v.120, 4073-4080 “Direct Electrochemistry of Myoglobin and Cytochrome P450 in Alternate Layer-by-Layer Films with DNA and other Polyions”
24. K. Ariga, Y. Lvov, T. Kunitake, J. Am. Chem. Soc., 1997, v.119, 2224-2231 "Assembling Alternate Dye-Polyion Molecular Films by Electrostatic Layer-by-Layer Adsorption"
25. Y. Lvov, I. Ichinose, T. Kunitake, J. Am. Chem. Soc., 1995, v.117, 6117-6122 "Assembly of Multicomponent Protein Films by Means of Electrostatic Layer-by-Layer Adsorption"
b. Books and chapters (published during last six years)
Books edited:
"Protein Architecture: Interfacial Molecular Assembly and Immobilization Biotechnology", Editors: Y. Lvov and H. Möhwald, 2000, Marcel Dekker Publ., NY, pp. 1-394.
“Bio-Inorganic Nanostructured Hybrid Materials,” Editors: E. Ruiz-Hitzky and Y. Lvov, 2006, Wiley Publ., London, Berlin, New York, pp. 1-320
Recent chapters in books
1. H. Ai, Y. Lvov, “Biomaterials Based on Layer-by-Layer Nanoassembly: Ultrathin Coating and Microencapsulation,” in book: Bottom-Up Nanofabrication: Supramolecules, Self-Assemblies, and Organized Films. Editor: K. Ariga, 2006, American Scientific Publishers, NY, pp. 124-146.
2. M. DeVilliers, Y. Lvov, “Nanocapsules for Drug Delivery,” in book: "Nanotechnologies for Life Sciences," Editor: C. Kumar, v.10, Wiley-VCH, Berlin, in press, 2006
3. M. McShane, Y. Lvov, “Layer-by-Layer Electrostatic Self-Assembly for Biomaterials,” in book Encyclopedia of Nanoscience & Nanotechnology, Ed. J. Schwartz, C. Contescu, M. Dekker Publ., p.1-24, 2005, NY.
4. T. Cui, Y. Lvov “Nanoassembly for Polymer Electronics,” in book Nanotechnology, Ed. H. Nalwa, 2004, Academic Press, NY, p.24-56.
5. D. Shchukin, G. Sukhorukov, Y. Lvov, “Nanoengineered Inorganic / Organic Composite Microcapsules,” in book Micro- Nano Integration, Ed. H. Knobloch, 2004, Springer, Berlin-London, p. 213-224.
6. K. Ariga, Y. Lvov “Self-Assembly of Functional Protein Multilayers: From Flat Films to Microtemplate Encapsulation”, in book: Biopolymers at Interfaces, Ed. M. Malmsten, M. Dekker Inc, 2003, NY, p.367-391.
7. I. Ichinose, Y. Lvov, T. Kunitake “Recent Progress in the Surface Sol-Gel Process and Protein Multilayers”, in book: Multilayer Thin Films: Sequential Assembly of Nanocomposite Materials. Eds. G. Decher, J. Schlenoff, J-M. Lehn, Wiley-VCH, 2003, p.245-262.
8. Y. Lvov "Polyion / Protein Nanostructures," In book: Encyclopedia of Surface and Colloid Science, Ed. A. Hubbard, 2002, Marcel Dekker, NY, p. 4162-4171.
9. Y. Lvov "Thin Film Nanofabrication by Alternate Adsorption of Polyions, Proteins and Nanoparticles," In book: Handbook for Surfaces and Interfaces, Volume 3: Nanostructured Materials, Ed: H. Nalwa, 2001, Academic Press, NY, p. 170-189.
10. Y. Lvov, "Electrostatic Layer-by-Layer Assembly of Proteins and Polyions." In book: Protein Architecture: Interfacial Molecular Assembly and Immobilization Biotechnology, Ed: Y. Lvov and H. Möhwald, 2000, Marcel Dekker Publ., NY, p. 125-167.
Presentations with published abstracts
Totally, more than 150 presentations; from them 60 reports were presented in 1999-2006. Below, the titles of major invited reports are given:
1. Y. Lvov, “Nanoparticle / Polyion Assembly on Microtemplates (Lipid Tubules, Latex Spheres),” 9LB-International Conference on Organized Molecular Films, 1 Sept 2000, Potsdam, Germany; Abstracts, p.60, – invited talk.
2. Y. Lvov “Nano-Assembly by Alternate Adsorption,” American Chemical Society PolyMillennial-2000, International Conference, Hawaii, 9 Dec, 2000, Abstracts, p.195, - invited talk.
3. Y. Lvov, Annual School of the Center for Advanced Microsystem Devices, LSU, Baton Rouge, June 12, 2001, “Organic Nanofilms,” Abstract, p.23-35. -invited lecture
4. Y. Lvov, Gordon Conference on Organic Thin Films, Salve Regina, June 28, 2001, “Nanoassembly by Alternate Adsorption of Oppositely Charged Components” – invited talk.
5. Y. Lvov, R. Besser, 223rd National American Chemical Society Meeting, Orlando, April 7-11, 2002, “Layer-by-Layer Polyion/Nanoparticle Assembly on 2D-Micropatterns and 3D-Microtemplates”- invited talk.
6. T. Cui, Y. Lvov, “Novel Lithography-Based Approaches to Pattern Layer-by-Layer Self-Assembled Thin Films,” ASME International Mechanical Engineering Congress, 2002, Nov 17-22, New Orleans – invited talk.
7. Y.Lvov, “Marriage” of LbL-Nanoassembly and Traditional Lithography for Microelectronics Element Production,” 226th National American Chemical Society Meeting, New York, September 9, 2003, Abstract #PMSE144 – invited talk.
8. Y. Lvov, “Nanoengineered Microcapsule for Chemical Reaction in Confined Volume,” 78th American Chemical Society, Colloid and Surface Science Meeting, New Haven, June 20, 2004 – invited talk.
9. Y. Lvov, “Electrostatic Layer-by-Layer Nanoassembly: Films, Micropatterns, Cantilevers, Nanocapsules,” OpticsEast, SPIE Conference, Nanofabrication: Technology and Devices, Philadelphia, October 26, 2004 – invited talk
10. Y. Lvov, “Pulp and Paper: Coating via Polyelectrolyte Nanoassembly and Synthesis in Microfiber’s Lumen,” 230th American Chemical Society National Meeting, Washington DC, August 28-September 1, 2005 – invited talk
Service
University Service
Co-chair of IfM-graduate bi-weekly seminar on Nanotechnology: “Functional Nanoassemblies: Fundamentals and Applications.” 72 reports were delivered at this seminar in the last four years.
Established LaTech collaboration with Max-Planck Institute for Colloids and Interfaces, Potsdam, Germany.
Established collaboration with National Institute of Materials Science, Tsukuba, Japan
Member of Steering Committee for MS/PhD program in Molecular Chemistry and Nanotechnology, LaTech.
Member of Steering Committee for Governor Biotechnology Initiative program, LaTech.
Member of Inst for Micromanufacturing Leadership team.
Professional Service
I was a panel referee for National Science Foundation panel on Nanoscale Centers, and NSF Chemistry Program 2004-2006; and a referee for National Institute of Health (NIH) –2003-2005; American Chemical Society Petroleum Foundation - 12 reviews during 2000-2006, and for Army Research Office, Mechanical Sciences Division (2002-2005). ● Reviewer for Congressionally Directed Medical Research Program, 2004-2005, projects on Targeted Nano-Therapeutics. ● Reviewer for US Civilian Research and Development Foundation on New Nanoparticle Materials, 2004-2006. ● Reviewer on Nanofiber Materials for US Army Research Office, 2005-2006
I was a Head of Organizing Committee of the American Chemical Society Symposium “Smart Nano-Assemblies,” New York Hilton Hotel, 7-10 Sept 2003. There were ca 150 participants from US, Germany, France, UK, Japan, China, and Russia at this interesting and successful symposium.
Chair of the future ACS Symposium “Nanoassembly: From Fundamental to Applications,” August 27-30, 2008, Philadelphia
In 1999-2006 I served as a peer referee for the following journals: Journal of American Chemical Society, Biomacromolecules, Langmuir, Macromolecules, Colloids and Surfaces: Engineering, J. Nanoscience and Nanotechnology, J. Physical Chemistry, Nano Letters, J. Colloid and Interface Sciences; J. Vacuum Science and Technology, Thin Solid Films, Analytical Chemistry, and Advanced Materials. More than 160 papers were reviewed for these prestigious international journals.
Member of Editorial Board of the Journal of Biomedical Nanotechnology
Teaching:
New graduate course “Nanofabrication by Self-Assembly” was prepared and taught for five years with an overage enrollment of about 24 students. The following courses were taught at Louisiana Tech University during last 6 years with average enrollment 50 students:
Undergraduate: General Physics, - PHYS 209 and 210; Physics for Engineers, - PHYS 201 and 202; Conceptual Physics,- PHYS 205 and 206.
Graduate: CHEM 523/450, and NSNT506 - “Nanofabrication by Self-Assembly,” MSE 505 - “Nanotechnology Principles,” MSE 501 - “Microsystem Principles”; MSE 512 - “Biotechnology Principles,” MSNT 504 – graduate nanotechnology seminar
Currently, I am a chair of advisory committee for 8 PhD grad students and 2 MS grad students. I was an advisor for four postdocs: Drs T. Shutova, Z. Lu, D. Schukin, G. Bantchev.
Industrial contracts: 2002-2003 contract with CIBA-Vision Corporation on eye lens biocompatible nanocoating; 2004-2006 contract with EPIC Therapeutics Inc, on insulin microencapsulation; and 2006-2007 contracts with SAPPI Fine Paper Corporation and with International Paper Company on nanotechnology for wood microfiber processing.
Last 5 years collaboration: National Institute of Standards (NIST) - S. Satija; Naval Research Laboratory - R. Price, and J. Schnur; University of Connecticut – J. Rusling; S. Suib; Max Planck Institute for Colloids and Interfaces - H. Moehwald; Queen Mary College, London University, G. Sukhorukov; and National Institute of Materials Sciences, Tsukuba, Japan - I. Ichinose, T. Kunitake
Additional Information
· Industry consulting: 1999-2000, BioRad Incorporation, Diagnostic Division; 2002 - Novartis Corporation; 2003 - Cabot Corporation; 2004 - Baxter Corporation; 2004 – International Paper Company; 2005 – Eeonyx Incorporation, 2005- nGimat Company, 2006-Weyerhaueser Corporation.
· Following the US Institute of Scientific Information (January, 2006), my citation index is more than 2,600 (excluding self-referencing). Two of my papers (in Journal of American Chemical Society and Langmuir) were cited 570 and 370 times, respectively. Another four papers (in Journal of American Chemical Society, Macromolecules, Langmuir, and Thin Solid Films) and book Protein Architecture were cited more than 200 time each.
· A nanoparticle helix figure from my paper in Langmuir, 2000, v.16, 5932-5935 “Nanoscale Patterning on Biologically Derived Microstructures” was published as a cover page picture for the July-2000 issue of this journal. An image of chiral liquid crystal from my paper in Chemistry Materials, 1999, v.11, 3196-31200, “Formation of Supramolecular Assemblies by Complementary association of Octadecyloxy Tartaric Acid and Bispyridyls” was published as a cover picture for the December-1999 issue of this journal.
My Advisors: PhD - Lev Feigin (Inst of Crystallography, Russian Academy of Sciences, Moscow); postdoctoral - Helmuth Moehwald, Max Planck Institute for Colloids and Interfaces, Germany, and Toyoki Kunitake, Tsukuba Research Center, Japan.