Biomedical Engineering 550 C

Spring, 1998

Cardiovascular Fluid Mechanics

 

 

Purpose: This course introduces concepts and models of Fluid Mechanics which are of particular use in understanding cardiovascular flows.  This includes the theory behind the concepts and specific applications in Biology and Medicine.

 

Reading assignments other than the handouts are from White’s Viscous Fluid Flow book.

 

Note that the dates listed below are tentative only.  Extra time is allowed at the end of the course to finish topics which go over their allotted time.

 

Lecture        Date             Topic                                                             Reading

1                  3/11/98         Course Rules, Vascular Physiology                  Handout

2                  3/13/98         Basic Equations                                               pp. 61-85

3                  3/16/98         Non Dimensionalization of Basic Equations         pp. 85-94

4                  3/18/98         Poiseuille Flow/Mean Arterial Shear Stress/       pp. 110-123

                                        Atherosclerosis & Intimal Hyperplasia

5                  3/20/98         Womersley Flow/Blood Flow Waveforms           Handout

6                  3/23/98

7                  3/25/98         Euler Flow/Stenoses                                        Handout

8                  3/27/98

9                  3/30/98         Vorticity, Stream Functions, Stokes Flow           pp. 94-107, 204-210

                                        and Blood Particles

10                4/1/98

11                4/3/98           Stagnation Point Flow                                      pp. 172-180

 

12                4/6/98           Pressure Drops in Stenoses                             Handout

13                4/8/98           Dean Flow/Curved Arteries                               Handout

14                4/10/98

15                4/13/98         Entry Flow/Simulation Models                           Handout

16                4/15/98         Orr-Summerfield Equations/Stenoses                pp. 385-415

17                4/17/98

18                4/20/98         Reynolds Decomposition/Cell Damage & Activation      pp. 453-466

19                4/22/98

20                4/24/98         Turbulent Kinetic Energy Equation/Hemolysis     Handout

21                4/27/98         Turbulent Couette Flow/Hemolysis                    Handout

22                4/29/98         Laser Anemometry                                          Handout

23                5/1/98           Shear Stress Measurement/Scaling Considerations                    Handout

24                5/4/98           Doppler Ultrasound                                          Handout

25                5/6/98           Hot Film Anemometry                                       Handout

26                5/8/98           Counter Current Multiplier/The Kidney               Handout

 

Questions of Interest to this Course:

                    Does low wall shear stress cause atherosclerosis?

                    Does turbulence cause red cell damage/platelet activation?

                    Does turbulence cause thrombosis?

                    Does high shear cause thrombosis?

                    Does low shear cause thrombosis?

                    Does low wall shear stress cause intimal hyperplasia?

                    Is particle residence time important in cardiovascular fluid mechanics?